منابع مشابه
The dichotomy of NMDA receptor signaling.
The N-methyl-D-aspartate (NMDA) subtype of ionotropic glutamate receptors plays a Jekyll and Hyde role in the mammalian central nervous system. In pathological scenarios such as ischemia, Ca2+ influx through the NMDA receptor is a key mediator of cell death. However, physiological levels of NMDA-receptor activity can promote neuronal survival and resistance to trauma and play important roles in...
متن کاملThe dichotomy of NMDA receptor signalling
The NMDA subtype of ionotropic glutamate receptors plays a Jekyll and Hyde role in the mammalian central nervous system. In pathological scenarios such as ischemia, Ca2+ influx through the NMDA receptor is a key mediator of cell death. However, physiological levels of NMDA receptor activity can promote neuronal survival and resistance to trauma, and play important roles in synaptic plasticity a...
متن کاملO 17: Childhood Anti-NMDA Receptor Encephalitis
Anti N-methyl-D-aspartate receptor (NMDR) encephalitis has been recognized as the most frequent autoimmune encephalitis in children after acute demyelinating encephalomyelitis (ADEM).However due to the variable the variable clinical presentation, the paucity of specific finding on standard laboratory and radiological investigation remains under recognized. First discribed in 2005, most commonly...
متن کاملNon-ionotropic signaling by the NMDA receptor: controversy and opportunity
Provocative emerging evidence suggests that the N-methyl-d-aspartate (NMDA) receptor can signal in the absence of ion flux through the receptor. This non-ionotropic signaling is thought to be due to agonist-induced conformational changes in the receptor, independently of channel opening. Non-ionotropic NMDA receptor signaling has been proposed to be sufficient to induce synaptic long-term depre...
متن کاملRegulation of NMDA-receptor synaptic transmission by Wnt signaling.
Wnt ligands are secreted glycoproteins controlling gene expression and cytoskeleton reorganization involved in embryonic development of the nervous system. However, their role in later stages of brain development, particularly in the regulation of established synaptic connections, is not known. We found that Wnt-5a acutely and specifically upregulates synaptic NMDAR currents in rat hippocampal ...
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ژورنال
عنوان ژورنال: The Neuroscientist
سال: 2007
ISSN: 1073-8584,1089-4098
DOI: 10.1177/1073858407305833